PRECLINICALTRIALS.EU
International register of preclinical trial protocols
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PreclinicalTrials is an online register of protocols for preclinical animal studies conducted around the world. Key features from the study protocol, including measures to reduce bias during the experiment(s), are recorded and maintained as a permanent record. PreclinicalTrials aims to provide a comprehensive listing of preclinical animal study protocols, preferably registered at inception, in order to increase transparency, help avoid duplication, and reduce the risk of reporting bias by enabling comparison of the completed study with what was planned in the protocol.

The aim of this registry is to:
  • Increase publication rate
  • Improve transition from bench to bedside
  • Reduce repetition of research and the number of laboratory animals used

Preclinicaltrials.eu is an initiative of the regenerative cardiovascular medicine research group at the University Medical Center Utrecht, The Netherlands.

This website serves as an example and ultimately registration of preclinical studies should be regulated by an independent and central organ.

For more information about this initiative please contact us at info@preclinicaltrials.eu or read our manuscript here.

Promoting transparency in preclinical research

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How to register a study

If you want to register first become a member to create an user account. Create a new record by filling out the online form. You can also download the registration form here*. Additional information on methods and specification of intervention is requested 1 year after starting date, which will be requested by an automatically sent email.
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Title Status Action
My first record submitted to the wonderful Preclincialtrials.eu Published
A second record on a completely different topic Published
Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop In process
Preservation of G i-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease In process
Preclinical antitumor activity of batracylin In process
Evaluating the validity of animal models for research into therapies for immune-based disorders In process
Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human In process
Imaging preclinical tumour models: improving translational power In process
The type I IFN signature as a biomarker of preclinical rheumatoid arthritis In process
Preclinical studies with toremifene as an antitumor agent In process
Foodstuffs for preventing cancer: the preclinical and clinical development of berries In process
Preclinical antitumor activity of 5-aza-2′-deoxycytidine agains human head and neck cancer xenografts In process
Quantitative interpretation of age-specific mortality reductions from the Swedish breast cancer-screening trials In process

Open data

Pre-clinical trials registry supports the concept of open data

We encourage the inclusion of our registry records in other applications. On this page you will find details of how to harvest our records etc etc

How to use this site

Pre-clinical trials registry help manual goes here

Preclinical trials study record

Register your study by completing the following form. Notice that the fields with an asterisk are mandatory, whereas other fields are optional. Questions 26 till 30 will be disclosed 1 year after the planned start date. Once data is submitted it will be checked before publication on this website. Changes made after publication on this site will be recorded with an audit trial.

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About this site

In our paper entitled ‘All preclinical trials should be registered in advance in an online registry’ we contemplate the seriousness of publication bias in both clinical and preclinical studies. We therefore promote the online registration of preclinical studies, just as is implemented for clinical trials. - Click here to read the article.

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For more information you can contact us at info@preclinicaltrials.eu

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