PRECLINICALTRIALS.EU
International register of preclinical trial protocols
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Preclinicaltrials aims to provide a comprehensive listing of preclinical animal study protocols.

Preferably registered at inception in order to increase transparency, help avoid duplication, and reduce the risk of reporting bias by enabling comparison of the completed study with what was planned in the protocol.

Registration of your study requires you to create an account that is

  • Anonymous
  • Free of charge
  • Has an optional embargo period

This register is web-based, open to all types of animal studies and freely accessible and searchable to all with a preclinicaltrials.eu account.

The registration form is designed by experts on preclinical animal studies and preclinical evidence synthesis.

Please join us and create an user account, this will provide access to the database and enables you to register your preclinical trial.

Contact us at info@preclinicaltrials.eu

Promoting transparency in preclinical research

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Log in to Preclinicaltrials.eu to search for records and submit your own protocols.

If you cannot log in make sure you are using the same email address that you registered with. If you have forgotten your password then please reset it using the Reset Password link above. If you are still having problems then please contact support@preclinicaltrials.eu.

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Type your search term above then click Go. Searches are performed on all published records and all fields. If you want to restrict your search to a particular field, select the appropriate field from the drop down list. You can browse all records by clicking Show all

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Use this form to email the author of the study.

Enter your message here. Please ensure you include your email address.

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How to register a study

From this page you can search the database, view your previous submissions or create a new record. You create a new record by filling out the online form.

Please make sure you search the database before starting a new submission to make sure a) the study has not already been registered and b) no-one else is undertaking the same work.

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My records

Listed below are all records you have previously created. You can continue to edit any record that has not been submitted for publication and you can view but not edit any record that has been submitted. You can create an updated version of any record that is published.

You do not have any records yet. Click Create to create a new Preclinicaltrials.eu record.

Open data

Pre-clinical trials registry supports the concept of open data

We encourage the inclusion of our registry records in other applications. On this page you will find details of how to harvest our records etc etc

Preclinical trials study record

Register your study by completing the following form. Notice that the fields with an asterisk are mandatory, whereas other fields are optional. Once the form is submitted it will be checked before publication on this website. Changes made after publication on this site will be recorded with an audit trail.

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About Preclinicaltrials.eu

Goals and aims of Preclinicaltrais.eu

Preclinicaltrials.eu aims to provide a comprehensive overview of all animal studies, including those that might otherwise remain unpublished. By (prospective) registration of animal studies we aim to:

  • Increase transparency
  • Avoid unnecessary duplication of animal studies
  • Reduce reporting bias, such as publication bias and bias induced by selective outcome reporting,  p-hacking and HARKing
  • Increase data sharing, by
    • allowing fellow researchers and reviewers to access information on the study design, which is often lacking in publications
    • provide a platform to share details and data of otherwise unpublished animal studies
  • Create opportunities for collaborative research
Which studies can you register on Preclinicaltrials.eu?

The register is open for all animal studies. We especially encourage researchers to register their confirmatory studies. This register is created with support of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes (TACTICS) alliance. Therefore the original focus is on the field of cardiac regenerative therapy. The design of the registration form is discussed with members of the TACTICS alliance. However, the register is open for studies from all fields of biomedical science. Furthermore, registration is not limited to a certain country or continent.

Steering committee of preclinicaltrials.eu

Prof Steven Chamuleau, MD, PhD

University Medical Center Utrecht, the Netherlands
Member of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes (TACTICS)

Prof Dirk Duncker, MD PhD

Board of the Netherlands Heart Institute

Mira van der Naald, MD

University Medical Center Utrecht, the Netherlands
Member of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes (TACTICS)

Kimberley Wever PhD

Systematic Review Center for Laboratory animal Experimentation (SYRCLE), Department of Health Evidence, Radboud university medical center, Nijmegen, The Netherlands
Advisory board of preclinicaltrials.eu

Prof Jonathan Kimmelman (McGill University, Montreal, Canada; Biomedical ethics)

Jonathan is a professor in biomedical ethics at the McGill University, Montreal, Canada. He is also the director of the biomedical unit of the faculty of medicine.

Prof. Paul Glasziou

Paul is a professor in evidence-based medicine at the Bond University, Gold Coast, Australia.

Prof John Ioannidis (Stanford University, Standford, USA; Health research and policy)

John is a professor of Medicine and Heath Research and Policy at the Standford University School of Medicine and a Professor of Statistics at Standford University School of Humanities and Science. He is also director of Standford Prevention Research Center, co-director of the Meta-Research Innovation Center at Standford (METRICS) and he is editor in chief of the European Journal of Clinical Investigation.

Prof. Annelien Bredenoord

Annelien is a professor of Ethics of Biomedical Innovation at the University Medical Center of Utrecht, The Netherlands. As of 2015, she us a member of the Dutch Senate (Eerste Kamer) on behalf of D66.

Prof. Lina Badimon

Lina is the director of the Cardiovascular Research Center (CSIC-ICCC) at the Autonomous University of Barcelona, Spain. She is also and co-founder & chief scientific officer of the European Society of Cardiology (ESC).

Prof.Thomas Eschenhagen

Thomas is a professor of Pharmacology at the University Medical Center Hamburg-Eppendorf, Germany. He is also Director of the department of Experimental Pharmacology and Toxicology. He is also one of the board of Directors of the DZHK, the German center for cardiovascular research.
Relevant literature

Kimmelman J – Should preclinical studies be registered?

Jansen of Lorkeers SJ – All preclinical trials should be registered in advance in an online registry

Chamuleau SAJ - Translational research in cardiovascular repair: A call for a paradigm shift

Preclinical systematic reviews and meta-analysis

The CAMARADES framework provides support for groups involved in preclinical systematic reviews and meta-analysis.

The SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) supports and trains researchers working with preclinical systematic reviews.

Registries for clinical trials

There are multiple registrations for clinical trials. The World Health Organisation provides additional information on these clinical trials.

The Dutch parliament passed a motion on July 3rd 2018 stating that prospective registration of animal studies and sharing of data should become the norm.

Internationally, we are supported by the TACTICS consortium and the European Society of Cardiology working group on cardiovascular regenerative and reparative medicine (ESC WG CARE). We plan to expand this line of international support.

Support for prospective registration of confirmatory animal studies

In The Netherlands we are now supported by funders, research institutes and research groups. The Royal Netherlands Academy of Arts and Sciences and the Netherlands Organization for Scientific Research are involved to guarantee permanent access to the database. Internationally, we are supported by the TACTICS consortium and the European Society of Cardiology working group on cardiovascular regenerative and reparative medicine (ESC WG CARE). We plan to expand this line of international support.

Contact

For more information you can contact us at info@preclinicaltrials.eu

News updates including congresses and workshops where preclinicaltrials.eu is involved

11 April 2018:
Offical launch of preclinicaltrials.eu
03 July 2018:
The Dutch parliament passed a motion stating that prospective registration of animal studies and sharing of data should become the norm
10-14 September 2018:
Eqipd summer school Radboud University
21 September 2018:
24 September 2018:
SGF Academy day
23-26 September 2018:
27 -28 November 2018:

Disclaimer

The information contained in this website is for general information purposes only and the safety and validity of a study on preclinicaltrials.eu is the responsibility of the study sponsor and investigator. The information is provided by preclinicaltrials.eu and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.

In no event will preclinicaltrials.eu or its developers be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website. Through this website you are able to link to other websites which are not under the control of preclinicaltrials.eu. While we make efforts to ensure the links are correct and up to date, we have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them and you use those links at your own risk.

Every effort is made to keep the website up and running smoothly. However, preclinicaltrials.eu takes no responsibility for, and will not be liable for, the website being unavailable due to technical issues.

Support for prospective registration of confirmatory animal studies

The Dutch parliament passed a motion on July 3rd 2018 stating that prospective registration of animal studies and sharing of data should become the norm.

In The Netherlands we are now supported by funders, research institutes and research groups. The Royal Netherlands Academy of Arts and Sciences and the Netherlands Organization for Scientific Research are involved to guarantee permanent access to the database. Internationally, we are supported by the TACTICS consortium and the European Society of Cardiology working group on cardiovascular regenerative and reparative medicine (ESC WG CARE). We plan to expand this line of international support.

Help with registration

1. How do I register?

Go to the homepage and click 'Join to create a user account' and fill in the form. We will send you an automatic email as confirmation and all you need to is click the link in that email to confirm your request. If you do not receive the automatic email within a few minutes check your Spam filters in case it has been blocked. If the message is there then please mark perclinicaltrials.eu as a safe sender so the filters do not block subsequent messages. If it’s still not there then please contact info@preclinicaltrials.eu for help.

2. Is registration free?

Yes

3. How do I submit a study?

Once you are logged in, click 'Create a new record' and simply complete the form. Once you are happy that you have answered all mandatory questions click the 'Submit for publication' button. If you find that you run out of time when filling in the form you can just click the 'Save changes for later' button and the information you have provided will be saved for later. You will not be able to submit the form if you have missed any mandatory questions, which will be highlighted in red for you when you click the 'Submit for publication' button.

4. Are personal details of researcher visible on the website?

You can choose if you want to share your contact details or if you would rather anonymize them. If you choose to anonymize your contact details, it will be possible for other members Preclinicaltrials.eu to contact you by an anonymized email address.

5. Will there be a time-stamped date on my protocol?

Yes. The protocol will be time-stamped on the date of submission and the date of publication.

6. What will happen with my submitted protocol?

Every submission will be checked if it is a protocol of an animal study and if it is filled out correctly. Importantly, no additional ethical or scientific review will be performed.

7. Will I be notified if my study has been accepted for publication?

Yes. You will receive an email when your record is accepted for publication. Your record will also be flagged as “published” in the “View my previous submissions” section.

8. Will my published protocol be openly accessible to everyone?

The database is accessible for anyone who has an account at www.preclinicaltrials.eu. You can choose per protocol whether you want to publish all data immediately, or if you want to have an embargo on the details of your protocol. If you choose to use the embargo, limited information will appear online immediately (Preclinicaltrials.eu ID, (anonymized) contact details, date of submission and sunrise date). The sunrise date is automatically set at 1 year after acceptance of your protocol.

9. If I choose the embargo, what data will be published immediately after approval?

A selection of data will be published immediately:

  • PreclinicalTrials.eu ID
  • (anonymized) contact details
  • Date of submission
  • Date of publication
10. I do not want to share sensitive data, also not after one year. Can I redact data?

No, you are not able to redact data. However, we mainly focus on the methodology of the study. Detailed descriptions on compounds or devices are not mandatory, one can even choose to register a study with for example “compound X”.

11. My study was rejected, am I able to re-submit it?

No. We will not reject a record unless it clearly does not meet our inclusion criteria. You are not able to re-submit a rejected record. You will receive and automatic email if your record is rejected. Your record will also be flagged as “rejected” in the “View my previous submissions” section. If you have any further questions, please contact us at info@preclinicaltrials.eu.

12. I am unable to edit a record that I have published?

Once a record is published it remains locked. Any revisions or updates that you want to make to that record must be done by creating an updated version. Click the “Update” button next to the record to start an update.

13. How do I contact preclinicaltrials.eu if I have an issue?

If you have questions or need assistance relating to an update or in general, e-mail info@preclinicaltrials.eu.