PRECLINICALTRIALS.EU
International register of preclinical trial protocols
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PreclinicalTrials is an online register of protocols for preclinical animal studies conducted around the world.

Key features from the study protocol including measures to reduce bias during the experiment(s) are recorded and maintained as a permanent record.

PreclinicalTrials aims to provide a comprehensive listing of preclinical animal study protocols, preferably registered at inception in order to increase transparency, help avoid duplication, and reduce the risk of reporting bias by enabling comparison of the completed study with what was planned in the protocol.

Please join us and create a user account, this will provide access to the database and enables you to register your preclinical trial.

For more information about this initiative please look at the about PreclinicalTrials.eu page, read our manuscripts (Jansen et al, Eur J Clin I, 2014 or Chamuleau, Circ Res, 2018)

Contact us at info@preclinicaltrials.eu. Technical issues are addressed on the help with registration page.

Promoting transparency in preclinical research

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Log in to PreclinicalTrials.eu to search for records and submit your own protocols.

If you cannot log in make sure you are using the same email address that you registered with. If you have forgotten your password then please reset it using the Reset Password link above. If you are still having problems then please contact support@preclinicaltrials.eu.

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Type your search term above then click Go. Searches are performed on all published records and all fields. If you want to restrict your search to a particular field, select the appropriate field from the drop down list. You can browse all records by clicking Show all

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Pre-clinical registry record

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Use this form to email the author of the study.

Enter your message here. Please ensure you include your email address.

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How to register a study

From this page you can search the database, view your previous submissions or create a new record. You create a new record by filling out the online form.

Please make sure you search the database before starting a new submission to make sure a) the study has not already been registered and b) no-one else is undertaking the same work.

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my previous submissions

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My records

Listed below are all records you have previously created. You can continue to edit any record that has not been submitted for publication and you can view but not edit any record that has been submitted. You can create an updated version of any record that is published.

You do not have any records yet. Click Create to create a new PreclinicalTrials.eu record.

Open data

Pre-clinical trials registry supports the concept of open data

We encourage the inclusion of our registry records in other applications. On this page you will find details of how to harvest our records etc etc

How to use this site

Pre-clinical trials registry help manual goes here

Preclinical trials study record

Register your study by completing the following form. Notice that the fields with an asterisk are mandatory, whereas other fields are optional. Once the form is submitted it will be checked before publication on this website. Changes made after publication on this site will be recorded with an audit trail.

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About PreclinicalTrials.eu

What is Preclinicaltrials.eu?

This website provides a platform to register animal studies. These studies are performed to help advance medical science. Unfortunately, not all the information gained by animal studies is shared as publications. Moreover, we know that studies with a negative or non-significant result have a smaller chance of getting published and that the time to publication for these studies is higher, leading to publication bias and an overestimation of effects. With this register we aim to provide a comprehensive listing of animal study protocols and thus increase transparency and help avoid unnecessary duplication. Furthermore, we aim to reduce the risk of reporting bias and increase the awareness of certain quality parameters (for example blinding and randomisation).

Which studies can you register on PreclinicalTrials.eu?

The register is open for all animal studies. We especially encourage researchers to register their confirmatory studies. This register is created with support of the Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes (TACTICS) alliance. Therefore the original focus is on the field of cardiac regenerative therapy. The design of the registration form is discussed with members of the TACTICS alliance. However, the register is open for studies from all fields of biomedical science. Furthermore, registration is not limited to a certain country or continent.

Who manages preclinicaltrials.eu?

The website is constructed by:
Drs. M. van der Naald (University Medical Center Utrecht)
Dr. K. Wever (SYstematic Review Center for Laboratory animal Experimentation, Radboud MC, Nijmegen)
Prof. Dr. S.A.J. Chamuleau (University Medical Center Utrecht, European Society of Cardiology working group on cardiovascular regenerative and reparative medicine (ESC WG CARE))

Website design:
Metaxis Ltd

Data managament:
Netherlands Heart Institute

Relevant literature

Kimmelman J – Should preclinical studies be registered?

Jansen of Lorkeers SJ – All preclinical trials should be registered in advance in an online registry

Chamuleau SAJ - Translational research in cardiovascular repair: A call for a paradigm shift

Preclinical systematic reviews and meta-analysis

The CAMARADES framework provides support for groups involved in preclinical systematic reviews and meta-analysis.

The SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) supports and trains researchers working with preclinical systematic reviews.

Registries for clinical trials

There are multiple registrations for clinical trials. The World Health Organisation provides additional information on these clinical trials.

Contact

For more information you can contact us at info@preclinicaltrials.eu

Disclaimer

The information contained in this website is for general information purposes only and the safety and validity of a study on preclinicaltrials.eu is the responsibility of the study sponsor and investigator. The information is provided by preclinicaltrials.eu and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.

In no event will preclinicaltrials.eu or its developers be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website. Through this website you are able to link to other websites which are not under the control of preclinicaltrials.eu. While we make efforts to ensure the links are correct and up to date, we have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them and you use those links at your own risk.

Every effort is made to keep the website up and running smoothly. However, preclinicaltrials.eu takes no responsibility for, and will not be liable for, the website being unavailable due to technical issues.

Support for prospective registration of confirmatory animal studies

The following organizations or initiatives have expressed their support for this database.

Help with registration

1. How do I register?

Go to the homepage and click 'Join to create a user account' and fill in the form. We will send you an automatic email as confirmation and all you need to is click the link in that email to confirm your request. If you do not receive the automatic email within a few minutes check your Spam filters in case it has been blocked. If the message is there then please mark perclinicaltrials.eu as a safe sender so the filters do not block subsequent messages. If it’s still not there then please contact info@preclinicaltrials.eu for help.

2. Is registration free?

Yes

3. How do I submit a study?

Once you are logged in, click 'Create a new record' and simply complete the form. Once you are happy that you have answered all mandatory questions click the 'Submit for publication' button. If you find that you run out of time when filling in the form you can just click the 'Save changes for later' button and the information you have provided will be saved for later. You will not be able to submit the form if you have missed any mandatory questions, which will be highlighted in red for you when you click the 'Submit for publication' button.

4. Are personal details of researcher visible on the website?

You can choose if you want to share your contact details or if you would rather anonymize them. If you choose to anonymize your contact details, it will be possible for other members PreclinicalTrials.eu to contact you by an anonymized email address.

5. Will there be a time-stamped date on my protocol?

Yes. The protocol will be time-stamped on the date of submission and the date of publication.

6. What will happen with my submitted protocol?

Every submission will be checked if it is a protocol of an animal study and if it is filled out correctly. Importantly, no additional ethical or scientific review will be performed.

7. Will I be notified if my study has been accepted for publication?

Yes. You will receive an email when your record is accepted for publication. Your record will also be flagged as “published” in the “View my previous submissions” section.

8. Will my published protocol be openly accessible to everyone?

The database is accessible for anyone who has an account at www.preclinicaltrials.eu. You can choose per protocol whether you want to publish all data immediately, or if you want to have an embargo on the details of your protocol. If you choose to use the embargo, limited information will appear online immediately (PreclinicalTrials.eu ID, (anonymized) contact details, date of submission and sunrise date). The sunrise date is automatically set at 1 year after acceptance of your protocol.

9. If I choose the embargo, what data will be published immediately after approval?

A selection of data will be published immediately:

  • PreclinicalTrials.eu ID
  • (anonymized) contact details
  • Date of submission
  • Date of publication
10. I do not want to share sensitive data, also not after one year. Can I redact data?

No, you are not able to redact data. However, we mainly focus on the methodology of the study. Detailed descriptions on compounds or devices are not mandatory, one can even choose to register a study with for example “compound X”.

11. My study was rejected, am I able to re-submit it?

No. We will not reject a record unless it clearly does not meet our inclusion criteria. You are not able to re-submit a rejected record. You will receive and automatic email if your record is rejected. Your record will also be flagged as “rejected” in the “View my previous submissions” section. If you have any further questions, please contact us at info@preclinicaltrials.eu.

12. I am unable to edit a record that I have published?

Once a record is published it remains locked. Any revisions or updates that you want to make to that record must be done by creating an updated version. Click the “Update” button next to the record to start an update.

13. How do I contact preclinicaltrials.eu if I have an issue?

If you have questions or need assistance relating to an update or in general, e-mail info@preclinicaltrials.eu.